The emergency services are dealing with a serious HGV collision on the southbound carriageway of the A19 about one mile from the Osmotherley junction.
The southbound carriageway is expected to remain closed for several hours with diversions in place.
Motorists are advised to avoid the area.
Highways England also had to close the nearby northbound carriage while they cleared mattresses and other debris from the road after the skip wagon shed its load having travelled on the A684 via Ellerbeck.
The northbound carriageway reopened at 12.25pm.
Both incidents were reported at around 10.30am today.
Witnesses or anyone with information are asked to make a report via the North Yorkshire Police website or by calling 101, option 1, and speak to the Force Control Room.
Please quote reference NYP-01022023-0142 when providing details.
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